WTAP Antikörper (full length)

Produktnummer ABIN7879326

Der Maus Monoklonal anti-WTAP Antikörper wird verwendet zum Nachweis von WTAP in Proben von Human. Er wurde validiert für IHC (p) und FACS.

Kurzübersicht für WTAP Antikörper (full length) (ABIN7879326)

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WTAP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: PCRP-WTAP-1A4

Produktdetails anti-WTAP Antikörper

Bindungsspezifität: full length

Verwendungszweck: WT1-associated protein Antibody / WTAP

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the WT1-associated protein antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the WT1-associated protein antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the WT1-associated protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu WTAP

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Andere Bezeichnung: WT1-associated protein

Hintergrund: Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.

UniProt: Q15007