Tropomyosin Antikörper (full length)

Produktnummer ABIN7879210

Der Maus Monoklonal anti-Tropomyosin Antikörper (Klon TPM1-4510) (ABIN7879210) detektiert spezifisch Tropomyosin in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Tropomyosin Antikörper (full length) (ABIN7879210)

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Tropomyosin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TPM1-4510

Produktdetails anti-Tropomyosin Antikörper

Bindungsspezifität: full length

Verwendungszweck: Alpha Tropomyosin Antibody / Tropomyosin-1 / TPM1

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Alpha Tropomyosin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Alpha Tropomyosin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Andere Bezeichnung: Alpha Tropomyosin

Hintergrund: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization