Tropomyosin Antikörper (AA 1-245)
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- Target Alle Tropomyosin (TPM1) Antikörper anzeigen
- Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))
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Bindungsspezifität
- AA 1-245
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Tropomyosin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Sequenz
- MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL ALNED
- Kreuzreaktivität
- Human, Maus, Ratte, Zebrafisch (Danio rerio)
- Produktmerkmale
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human Tropomyosin 1 (NP_001018008.1).
- Isotyp
- IgG
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- Applikationshinweise
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid freeze / thaw cycles
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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-
Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos." in: Scientific reports, Vol. 7, Issue 1, pp. 4022, (2018) (PubMed).
: "
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Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos." in: Scientific reports, Vol. 7, Issue 1, pp. 4022, (2018) (PubMed).
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- Target
- Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))
- Andere Bezeichnung
- TPM1 (TPM1 Produkte)
- Hintergrund
- This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.,TPM1,C15orf13,CMD1Y,CMH3,HEL-S-265,HTM-alpha,LVNC9,TMSA,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Actins,Cardiovascular,Heart,Hypertrophy,TPM1
- Molekulargewicht
- 26 kDa/28 kDa/32 kDa
- Gen-ID
- 7168
- UniProt
- P09493
- Pathways
- Regulation of Actin Filament Polymerization
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