TMPRSS2 Antikörper (full length)

Produktnummer ABIN7879195

Der Maus Monoklonal anti-TMPRSS2 Antikörper (Klon TMPRSS2-7410) (ABIN7879195) detektiert spezifisch TMPRSS2 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TMPRSS2 Antikörper (full length) (ABIN7879195)

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TMPRSS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TMPRSS2-7410

Produktdetails anti-TMPRSS2 Antikörper

Bindungsspezifität: full length

Verwendungszweck: TMPRSS2 Antibody / Transmembrane protease serine 2 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human TMPRSS2 protein was used as the immunogen for the TMPRSS2 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TMPRSS2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TMPRSS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TMPRSS2

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Andere Bezeichnung: TMPRSS2

Hintergrund: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interaktom