SOX4 Antikörper (full length)

Produktnummer ABIN7879075

Der Maus Monoklonal anti-SOX4 Antikörper (Klon SOX4-2540) (ABIN7879075) detektiert spezifisch SOX4 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SOX4 Antikörper (full length) (ABIN7879075)

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: SOX4-2540

Produktdetails anti-SOX4 Antikörper

Bindungsspezifität: full length

Verwendungszweck: SOX4 Antibody (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Full length recombinant human protein was used as the immunogen for the SOX4 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SOX4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the SOX4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu SOX4

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Andere Bezeichnung: SOX4

Hintergrund: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-AŽ ²-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

UniProt: Q06945