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SOX4 Antikörper

SOX4 Reaktivität: Human IHC, StM Wirt: Maus Monoclonal SOX4-2540 unconjugated
Produktnummer ABIN6940617
  • Target Alle SOX4 Antikörper anzeigen
    SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))
    Reaktivität
    • 38
    • 20
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 32
    • 6
    Maus
    Klonalität
    • 33
    • 5
    Monoklonal
    Konjugat
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SOX4 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 17
    • 13
    • 13
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human SOX4 protein
    Klon
    SOX4-2540
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product SOX4 Primärantikörper
  • Applikationshinweise

    Positive Control: Breast or Colon Carcinoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))
    Andere Bezeichnung
    SOX4 (SOX4 Produkte)
    Synonyme
    EVI16 antikoerper, AA682046 antikoerper, Sox-4 antikoerper, sox4 antikoerper, wu:fb82f08 antikoerper, wu:fq41g10 antikoerper, zgc:65850 antikoerper, zgc:77392 antikoerper, SRY-box 4 antikoerper, SRY box 4 antikoerper, SRY (sex determining region Y)-box 4 antikoerper, SRY (sex determining region Y)-box 4a antikoerper, SOX4 antikoerper, Sox4 antikoerper, sox4a antikoerper
    Hintergrund
    SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.
    Molekulargewicht
    47kDa
    Gen-ID
    6659
    UniProt
    Q06945
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