Rekombinanter Retinoblastoma Protein (Rb) Antikörper (full length)

Produktnummer ABIN7878912

Der Kaninchen Monoklonal anti-Retinoblastoma Protein (Rb) Antikörper wird verwendet zum Nachweis von Retinoblastoma Protein (Rb) in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Retinoblastoma Protein (Rb) Antikörper (full length) (ABIN7878912)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma Protein (Rb) Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: RB1-7080R

Produktdetails anti-Retinoblastoma Protein (Rb) Antikörper

Bindungsspezifität: full length

Verwendungszweck: Recombinant Retinoblastoma Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Andere Bezeichnung: Retinoblastoma

Hintergrund: Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases