POU1F1 Antikörper (full length)

Produktnummer ABIN7878831

Der Maus Monoklonal anti-POU1F1 Antikörper wird verwendet zum Nachweis von POU1F1 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für POU1F1 Antikörper (full length) (ABIN7878831)

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POU1F1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: PIT1-7262

Produktdetails anti-POU1F1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: POU1F1 Antibody / PIT-1 / GHF-1 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant human full-length protein was used as the immunogen for the POU1F1 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the POU1F1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the POU1F1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu POU1F1

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Andere Bezeichnung: POU1F1

Hintergrund: Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process