POU1F1 Antikörper

Produktnummer ABIN7861945

Der Maus Monoklonal anti-POU1F1 Antikörper (Klon PIT1-7262) (ABIN7861945) detektiert spezifisch POU1F1 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für POU1F1 Antikörper (ABIN7861945)

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POU1F1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: PIT1-7262

Produktdetails anti-POU1F1 Antikörper

Verwendungszweck: POU1F1 / PIT-1 Antibody

Spezifität: Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human full-length POU1F1 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu POU1F1

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Andere Bezeichnung: POU1F1

Hintergrund:

Dwarf, GHF1A, Growth hormone factor 1, Hmp1, PiT-1, Pit1 beta, PIT1Z, Pituitary growth hormone, Pituitary specific positive transcription factor 1, POU domain class 1 transcription factor 1, POU domain transcriptional regulator, POU1F1

Human pituitary or tonsil.

Molekulargewicht: 31-35kDa

Gen-ID: 5449, 591654

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process