KDM5C Antikörper (full length)

Produktnummer ABIN7878545

Dieser Maus Monoklonal Antikörper detektiert spezifisch KDM5C in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KDM5C Antikörper (full length) (ABIN7878545)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KDM5C Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-KDM5C-1A11

Produktdetails anti-KDM5C Antikörper

Bindungsspezifität: full length

Verwendungszweck: JARID1C Antibody / KDM5C / SMCX

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the JARID1C antibody.

Isotyp: IgG2c

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the JARID1C antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the JARID1C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Andere Bezeichnung: JARID1C

Hintergrund: SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

UniProt: P41229

Pathways: Warburg Effekt