LIM Domain Binding 2 Protein Antikörper (full length)

Produktnummer ABIN7878536

Dieser Maus Monoklonal Antikörper detektiert spezifisch LIM Domain Binding 2 Protein in IF, IHC (p) und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für LIM Domain Binding 2 Protein Antikörper (full length) (ABIN7878536)

Target: LIM Domain Binding 2 Protein (LDB2) (LIM Domain Binding 2 (LDB2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LIM Domain Binding 2 Protein Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-LDB2-1B10

Produktdetails anti-LIM Domain Binding 2 Protein Antikörper

Bindungsspezifität: full length

Verwendungszweck: LDB2 Antibody / LIM domain binding 2 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human LDB2 protein was used as the immunogen for the LDB2 antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LDB2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the LDB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu LIM Domain Binding 2 Protein

Target: LIM Domain Binding 2 Protein (LDB2) (LIM Domain Binding 2 (LDB2))

Andere Bezeichnung: LDB2

Hintergrund: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

UniProt: O43679

Pathways: Stem Cell Maintenance