Keratin 6B Antikörper (full length)

Produktnummer ABIN7878504

Der Maus Monoklonal anti-Keratin 6B Antikörper wird verwendet zum Nachweis von Keratin 6B in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Keratin 6B Antikörper (full length) (ABIN7878504)

Target: Keratin 6B (KRT6B)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 6B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: KRT6B-2116

Produktdetails anti-Keratin 6B Antikörper

Bindungsspezifität: full length

Verwendungszweck: Cytokeratin 6B Antibody (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant full-length human KRT6B protein was used as the immunogen for the Cytokeratin 6B antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Cytokeratin 6B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Cytokeratin 6B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Keratin 6B

Target: Keratin 6B (KRT6B)

Andere Bezeichnung: Cytokeratin 6B

Hintergrund: This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

UniProt: P04259