Keratin 6B Antikörper

Produktnummer ABIN7863057

Dieser Maus Monoklonal Antikörper detektiert spezifisch Keratin 6B in IHC. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Keratin 6B Antikörper (ABIN7863057)

Target: Keratin 6B (KRT6B)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 6B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: KRT6B-2116

Produktdetails anti-Keratin 6B Antikörper

Verwendungszweck: Cytokeratin 6B (KRT6B) (Basal Cell Marker) Antibody

Spezifität: This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human KRT6B protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Keratin 6B

Target: Keratin 6B (KRT6B)

Andere Bezeichnung: Cytokeratin 6B

Hintergrund:

CK6B, Keratin Type II Cytoskeletal 6B, KRT6B

Tonsil or basal cell carcinoma

Molekulargewicht: 56kDa

Gen-ID: 3854, 700779

UniProt: P04259