GPN1 Antikörper (full length)

Produktnummer ABIN7878316

Der Maus Monoklonal anti-GPN1 Antikörper (Klon GPN1-2350) (ABIN7878316) detektiert spezifisch GPN1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GPN1 Antikörper (full length) (ABIN7878316)

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GPN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Güteklasse: Carrier-free

Klon: GPN1-2350

Produktdetails anti-GPN1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: XAB1 Antibody / GPN1 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant full length human protein was used as the immunogen for this XAB1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the XAB1 antibody to be titered up or down for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the XAB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu GPN1

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Andere Bezeichnung: XAB1

Hintergrund: GPN1 (GPN-loop GTPase 1), also called XAB1 (XPA-binding protein 1) is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating it in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that it has possible GTPase activity.

UniProt: Q9HCN4