Calpastatin Antikörper (full length)

Produktnummer ABIN7877762

Dieser Maus Monoklonal Antikörper detektiert spezifisch Calpastatin in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Calpastatin Antikörper (full length) (ABIN7877762)

Target: Calpastatin (CAST)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calpastatin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CAST-1550

Produktdetails anti-Calpastatin Antikörper

Bindungsspezifität: full length

Verwendungszweck: Calpastatin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant full-length human CAST protein was used as the immunogen for this Calpastatin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Calpastatin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Calpastatin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Calpastatin

Target: Calpastatin (CAST)

Andere Bezeichnung: Calpastatin

Hintergrund: Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpastatin, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P20810