Calcineurin B Antikörper (full length)

Produktnummer ABIN7877754

Der Maus Monoklonal anti-Calcineurin B Antikörper wird verwendet zum Nachweis von Calcineurin B in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Calcineurin B Antikörper (full length) (ABIN7877754)

Target: Calcineurin B (CAN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calcineurin B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: BE2-1

Produktdetails anti-Calcineurin B Antikörper

Bindungsspezifität: full length

Verwendungszweck: Calcineurin B Antibody / PPP3R1

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant full-length human Calcineurin B protein was used as the immunogen for the Calcineurin B antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Calcineurin B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Calcineurin B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Calcineurin B

Target: Calcineurin B (CAN)

Andere Bezeichnung: Calcineurin B

Hintergrund: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

UniProt: P63098

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling