BCL11A Antikörper (full length)

Produktnummer ABIN7877690

Dieser Maus Monoklonal Antikörper detektiert spezifisch BCL11A in ELISA, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BCL11A Antikörper (full length) (ABIN7877690)

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL11A Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-BCL11A-1H3

Produktdetails anti-BCL11A Antikörper

Bindungsspezifität: full length

Verwendungszweck: B-cell lymphoma/leukemia 11A Antibody / BCL11A (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the B-cell lymphoma/leukemia 11A antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the B-cell lymphoma/leukemia 11A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the B-cell lymphoma/leukemia 11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu BCL11A

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Andere Bezeichnung: B-cell lymphoma/leukemia 11A

Hintergrund: Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

UniProt: Q9H165

Pathways: Regulation of Cell Size