ISR-alpha Antikörper (Extracellular)

Produktnummer ABIN7877547

Der Maus Monoklonal anti-ISR-alpha Antikörper wird verwendet zum Nachweis von ISR-alpha in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für ISR-alpha Antikörper (Extracellular) (ABIN7877547)

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ISR-alpha Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: INSR-1661

Produktdetails anti-ISR-alpha Antikörper

Bindungsspezifität: Extracellular

Verwendungszweck: Insulin Receptor alpha Antibody (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Insulin Receptor alpha antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ISR-alpha

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Andere Bezeichnung: Insulin Receptor alpha

Hintergrund: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

UniProt: P06213