BTLA Antikörper (Extracellular)

Produktnummer ABIN7877535

Der Maus Monoklonal anti-BTLA Antikörper wird verwendet zum Nachweis von BTLA in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für BTLA Antikörper (Extracellular) (ABIN7877535)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BTLA Antikörper ist unkonjugiert

Applikation: ELISA

Klon: BTLA-1528

Produktdetails anti-BTLA Antikörper

Bindungsspezifität: Extracellular

Verwendungszweck: BTLA Antibody / CD272

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BTLA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Andere Bezeichnung: BTLA

Hintergrund: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints