FAT1 Antikörper (Cytoplasmic Domain)

Produktnummer ABIN7877531

Dieser Maus Monoklonal Antikörper detektiert spezifisch FAT1 in ELISA, WB und IF. Es zeigt Reaktivität gegenüber Proben von Drosophila melanogaster.

Kurzübersicht für FAT1 Antikörper (Cytoplasmic Domain) (ABIN7877531)

Target: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Reaktivität: Drosophila melanogaster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAT1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Güteklasse: Carrier-free

Klon: FAT1-3D7-1

Produktdetails anti-FAT1 Antikörper

Bindungsspezifität: Cytoplasmic Domain

Verwendungszweck: FAT1 Antibody (Drosophila melanogaster) (azide and preservative free)

Aufreinigung: PEG precipitation

Immunogen: The cytoplasmic domain of Drosophila Fat protein was used as the immunogen for the FAT1 antibody.

Isotyp: IgM, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FAT1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the FAT1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu FAT1

Target: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Andere Bezeichnung: FAT1

Hintergrund: The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.

UniProt: Q14517