NCR3 Antikörper (C-Term)

Produktnummer ABIN7877437

Der Kaninchen Polyklonal anti-NCR3 Antikörper (ABIN7877437) detektiert spezifisch NCR3 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für NCR3 Antikörper (C-Term) (ABIN7877437)

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NCR3 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: NCR3 Antibody / Natural cytotoxicity receptor 3

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human NCR3 was used as the immunogen for the NCR3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NCR3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NCR3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NCR3

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Andere Bezeichnung: NCR3

Hintergrund: NCR3 antibody detects Natural cytotoxicity receptor 3, an activating receptor expressed on the surface of natural killer (NK) cells that mediates cytotoxic responses against virus-infected and tumor cells. The UniProt recommended name is Natural cytotoxicity receptor 3 (NCR3). Also known as NKp30, this receptor is a member of the immunoglobulin superfamily and plays a key role in innate immune surveillance and antitumor defense.

Functionally, NCR3 antibody identifies a 190-amino-acid type I transmembrane protein containing a single extracellular immunoglobulin-like domain responsible for ligand recognition. NCR3 binds to several cellular and pathogen-derived ligands, including B7-H6, BAG6, and viral hemagglutinin, triggering NK cell activation and cytotoxic granule release. Engagement of NCR3 leads to downstream signaling through the ITAM-containing adaptor protein CD3 zeta, resulting in cytokine production (IFN-gamma, TNF-alpha) and target cell killing. Beyond its role in NK cells, NCR3 expression has also been detected in subsets of T cells and innate lymphoid cells, where it contributes to immune modulation and inflammation.

The NCR3 gene is located on chromosome 6p21.3 within the major histocompatibility complex (MHC) region. Expression is tightly regulated by cytokines such as IL-2 and IL-15, which promote NK cell activation and expansion. NCR3 activity is balanced by interactions with both activating and inhibitory receptors to maintain immune homeostasis.

Pathologically, dysregulated NCR3 signaling influences susceptibility to infections, tumor immune evasion, and autoimmune conditions. Reduced receptor expression or function can impair NK cell cytotoxicity, while overactivation contributes to tissue inflammation and autoimmunity. Elevated NCR3 activity has been reported in various cancers and viral infections, highlighting its importance as a biomarker for immune activation and immunotherapy potential. Research using NCR3 antibody supports studies in NK cell biology, tumor immunology, and antiviral defense.

NCR3 antibody is validated for use in relevant research applications to study receptor-mediated cytotoxicity and immune signaling. NSJ Bioreagents provides NCR3 antibody reagents optimized for investigations into NK cell activation, immunoreceptor signaling, and immune regulation.

UniProt: O14931

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process