GZMM Antikörper (C-Term)

Produktnummer ABIN7877389

Der Kaninchen Polyklonal anti-GZMM Antikörper (ABIN7877389) detektiert spezifisch GZMM in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GZMM Antikörper (C-Term) (ABIN7877389)

Target: GZMM (Granzyme M (Lymphocyte Met-Ase 1) (GZMM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GZMM Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-GZMM Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: GZMM Antibody / Granzyme M

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme M/GZMM was used as the immunogen for the GZMM antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GZMM antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GZMM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GZMM

Target: GZMM (Granzyme M (Lymphocyte Met-Ase 1) (GZMM))

Andere Bezeichnung: GZMM

Hintergrund: GZMM antibody detects Granzyme M, a serine protease expressed in cytotoxic lymphocytes and natural killer (NK) cells that mediates immune defense through target cell apoptosis. The UniProt recommended name is Granzyme M (GZMM). This enzyme contributes to innate immunity by inducing non-caspase-dependent cell death and by modulating inflammatory cytokine processing.

Functionally, GZMM antibody identifies a 262-amino-acid protein localized to cytotoxic granules of NK and CD8+ T cells. Granzyme M is stored in secretory vesicles and released upon immune activation to cleave intracellular substrates in infected or malignant cells. It works synergistically with perforin and other granzymes to initiate rapid target cell lysis.

The GZMM gene is located on chromosome 19p13.3 within the granzyme gene cluster and is expressed predominantly in NK cells and cytotoxic T lymphocytes. GZMM contributes to immune surveillance by degrading viral and bacterial proteins and modulating proinflammatory signaling pathways.

Pathologically, elevated GZMM activity has been observed in inflammatory and autoimmune diseases, as well as in cancer immune responses. Deficiency impairs cytotoxic clearance of pathogens and tumor cells. Research using GZMM antibody supports studies in immunology, cytotoxic signaling, and inflammation control.

GZMM antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cytotoxic granule enzymes. NSJ Bioreagents provides GZMM antibody reagents optimized for immune cell function, cytotoxicity, and inflammation research.

Structurally, Granzyme M is a trypsin-like serine protease containing the catalytic triad His-Asp-Ser and a substrate-binding pocket that determines cleavage specificity. This antibody aids in examining GZMM's role in cytotoxic defense and immune regulation.

UniProt: P51124