Cathepsin S Antikörper (C-Term)

Produktnummer ABIN7877329

Der Kaninchen Polyklonal anti-Cathepsin S Antikörper (ABIN7877329) detektiert spezifisch Cathepsin S in WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Cathepsin S Antikörper (C-Term) (ABIN7877329)

Target: Cathepsin S (CTSS)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Cathepsin S Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CTSS Antibody / Cathepsin S

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CTSS was used as the immunogen for the CTSS antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CTSS antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CTSS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Cathepsin S

Target: Cathepsin S (CTSS)

Andere Bezeichnung: CTSS

Hintergrund: CTSS antibody detects Cathepsin S, a lysosomal cysteine protease that degrades extracellular matrix and participates in antigen processing. The UniProt recommended name is Cathepsin S (CTSS). This proteolytic enzyme plays a central role in endosomal protein degradation and MHC class II-mediated antigen presentation, particularly within antigen-presenting cells such as macrophages and dendritic cells.

Functionally, CTSS antibody identifies a 331-amino-acid protein synthesized as an inactive proenzyme that undergoes autocatalytic cleavage to form an active mature enzyme in acidic endosomes. Cathepsin S hydrolyzes invariant chain peptides to allow loading of antigenic peptides onto MHC class II molecules, supporting adaptive immune responses. It also contributes to extracellular matrix remodeling during inflammation and immune cell migration.

The CTSS gene is located on chromosome 1q21.3 and is highly expressed in lymphoid tissues and mononuclear phagocytes. Cathepsin S activity is regulated by cystatin protease inhibitors and by pH -dependent activation within the lysosomal environment. Its stability at neutral pH distinguishes it from other cathepsins, enabling extracellular activity during inflammation.

Pathologically, excessive CTSS activity has been associated with autoimmune diseases, atherosclerosis, and cancer. Inhibiting CTSS reduces antigen presentation and inflammatory damage, making it a therapeutic target for chronic inflammatory disorders. Research using CTSS antibody supports studies in immunology, inflammation, and protease biology.

CTSS antibody is validated for western blotting, immunohistochemistry, and enzymatic assays to detect Cathepsin S in immune tissues and cultured cells. NSJ Bioreagents provides high-quality CTSS antibody reagents optimized for proteolytic enzyme and immune pathway research.

Structurally, Cathepsin S belongs to the papain family of cysteine proteases and contains a catalytic dyad of cysteine and histidine within its active site. This antibody facilitates detection and quantification of CTSS in studies of antigen processing, protease regulation, and immune signaling.

UniProt: P25774

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades