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NEDD4-2 Antikörper (pSer342) (Biotin)

This anti-NEDD4-2 antibody (ABIN744250) is a Rabbit Polyclonal antibody detecting NEDD4-2 in ELISA, IHC (p), IHC (fro). Suitable for Human.
Produktnummer ABIN744250

Quick Overview for NEDD4-2 Antikörper (pSer342) (Biotin) (ABIN744250)

Target

Alle NEDD4-2 (NEDD4L) Antikörper anzeigen
NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Reaktivität

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  • 1
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Human

Wirt

  • 63
  • 4
Kaninchen

Klonalität

  • 58
  • 9
Polyklonal

Konjugat

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  • 2
  • 2
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Dieser NEDD4-2 Antikörper ist konjugiert mit Biotin

Applikation

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 8
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    • 3
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    • 2
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    pSer342

    Homologie

    Human,Mouse,Rat,Cow,Pig,Horse,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human NEDD4L around the phosphorylation site of Ser342

    Isotyp

    IgG
  • Applikationshinweise

    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

    Andere Bezeichnung

    NEDD4L

    Hintergrund

    Synonyms: E3 ubiquitin protein ligase NEDD4 like protein, E3 ubiquitin-protein ligase NEDD4-like, E3 ubiquitin-protein ligase NEDD4-like protein, KIAA0439, NED4L_HUMAN, NEDD4 2, NEDD4 2c, NEDD4-2, NEDD4-2a, NEDD4.2, NEDD4b, NEDD4L, NEDD4La, NEDD4Lb, NEDD4Lc, NEDD4Ld, NEDD4Le, NEDD4Lf, NEDD4Lg, NEDD4Lh, NEDL3, Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase, Neural precursor cell expressed, developmentally down regulated 4 like, RSP5, Ubiquitin protein ligase Rsp5.

    Background: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.

    Gen-ID

    23327

    Pathways

    Negative Regulation of Transporter Activity
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