NKX3-1 Antikörper (AA 92-224)

Produktnummer ABIN7877168

Dieser Maus Monoklonal Antikörper detektiert spezifisch NKX3-1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NKX3-1 Antikörper (AA 92-224) (ABIN7877168)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NKX3-1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: NKX3-1-2576

Produktdetails anti-NKX3-1 Antikörper

Bindungsspezifität: AA 92-224

Verwendungszweck: NKX3.1 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human NKX3.1 protein fragment within amino acids 92-224 was used as the immunogen for the NKX3.1 antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NKX3.1 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the NKX3.1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Andere Bezeichnung: NKX3.1

Hintergrund: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus