GPBAR1 Antikörper (AA 76-310)

Produktnummer ABIN7876743

Der Kaninchen Polyklonal anti-GPBAR1 Antikörper wird verwendet zum Nachweis von GPBAR1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für GPBAR1 Antikörper (AA 76-310) (ABIN7876743)

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPBAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-GPBAR1 Antikörper

Bindungsspezifität: AA 76-310

Verwendungszweck: TGR5 Antibody / GPBAR1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N76-S310) was used as the immunogen for the TGR5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TGR5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TGR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GPBAR1

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Andere Bezeichnung: TGR5

Hintergrund: The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) and TGR5 as is a protein that in humans is encoded by the GPBAR1 gene. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

UniProt: Q8TDU6

Pathways: WNT Signalweg, Hormone Transport, Sensory Perception of Sound