CD276 Antikörper (AA 7-3)

Produktnummer ABIN7876479

Der Maus Monoklonal anti-CD276 Antikörper wird verwendet zum Nachweis von CD276 in Proben von Human. Er wurde validiert für WB, IHC (p) und ICC.

Kurzübersicht für CD276 Antikörper (AA 7-3) (ABIN7876479)

Target: CD276

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD276 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Klon: 2009CT652-35-9

Produktdetails anti-CD276 Antikörper

Bindungsspezifität: AA 7-3

Verwendungszweck: B7-H3 Antibody / CD276

Aufreinigung: Protein G affinity

Immunogen: Recombinant human protein was used as the immunogen for the B7-H3 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the B7-H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CD276

Target: CD276

Andere Bezeichnung: B7-H3

Hintergrund: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints