WFS1 Antikörper (AA 61-313)

Produktnummer ABIN7876107

Der Kaninchen Polyklonal anti-WFS1 Antikörper wird verwendet zum Nachweis von WFS1 in Proben von Human und Affe. Er wurde validiert für WB, ELISA, IF, IHC (p) und FACS.

Kurzübersicht für WFS1 Antikörper (AA 61-313) (ABIN7876107)

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WFS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-WFS1 Antikörper

Bindungsspezifität: AA 61-313

Verwendungszweck: Wolframin Antibody / WFS1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A61-H313) was used as the immunogen for the Wolframin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Wolframin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Wolframin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu WFS1

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Andere Bezeichnung: Wolframin

Hintergrund: Wolframin is a protein that in humans is encoded by the WFS1 gene. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.

UniProt: O76024

Pathways: Sensory Perception of Sound, Carbohydrate Homeostasis, ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom