CYB561 Antikörper (AA 579-607)

Produktnummer ABIN7875834

Der Kaninchen Polyklonal anti-CYB561 Antikörper wird verwendet zum Nachweis von CYB561 in Proben von Human. Er wurde validiert für WB, FACS und IHC (p).

Kurzübersicht für CYB561 Antikörper (AA 579-607) (ABIN7875834)

Target: CYB561 (Cytochrome B-561 (CYB561))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYB561 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CYB561 Antikörper

Bindungsspezifität: AA 579-607

Verwendungszweck: Pyruvate Dehydrogenase E2 Antibody / DLAT

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 579-607 from the human protein was used as the immunogen for the Pyruvate Dehydrogenase E2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Pyruvate Dehydrogenase E2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Pyruvate Dehydrogenase E2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CYB561

Target: CYB561 (Cytochrome B-561 (CYB561))

Andere Bezeichnung: Pyruvate Dehydrogenase E2

Hintergrund: DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

UniProt: P10515