Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MAGE-Like 2 in ELISA, WB, IHC (p) und FACS. Es zeigt Reaktivität gegenüber Proben von Human.
MAGEL2
Reaktivität: Human
ELISA, IHC
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
Optimal dilution of the MAGEL2 antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
After reconstitution, the MAGEL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Target
MAGE-Like 2 (MAGEL2)
Andere Bezeichnung
MAGEL2
Hintergrund
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.