MERTK Antikörper (AA 55-148)

Produktnummer ABIN7875677

Dieser Maus Monoklonal Antikörper detektiert spezifisch MERTK in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MERTK Antikörper (AA 55-148) (ABIN7875677)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MERTK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MERTK-3024

Produktdetails anti-MERTK Antikörper

Bindungsspezifität: AA 55-148

Verwendungszweck: MERTK Antibody

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 55-148 was used as the immunogen for the MERTK antibody.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MERTK antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MERTK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MERTK

Hintergrund: MERTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MERTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MERTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MERTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MERTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

UniProt: Q12866

Pathways: RTK Signalweg