GIMAP4 Antikörper (AA 53-224)

Produktnummer ABIN7875592

Der Kaninchen Polyklonal anti-GIMAP4 Antikörper (ABIN7875592) detektiert spezifisch GIMAP4 in WB, ELISA, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für GIMAP4 Antikörper (AA 53-224) (ABIN7875592)

Target: GIMAP4 (GTPase, IMAP Family Member 4 (GIMAP4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GIMAP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-GIMAP4 Antikörper

Bindungsspezifität: AA 53-224

Verwendungszweck: GIMAP4 Antibody / GTPase IMAP family member 4

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human GIMAP4 recombinant protein (Position: R53-R224) was used as the immunogen for the GIMAP4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GIMAP4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GIMAP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GIMAP4

Target: GIMAP4 (GTPase, IMAP Family Member 4 (GIMAP4))

Andere Bezeichnung: GIMAP4

Hintergrund: GIMAP4 antibody detects GTPase IMAP family member 4, encoded by the GIMAP4 gene. GTPase IMAP family member 4 is a small GTP binding protein expressed in lymphoid tissues, where it regulates apoptosis and immune homeostasis. GIMAP4 antibody provides researchers with a tool for studying lymphocyte biology, programmed cell death, and immune regulation.

GTPase IMAP family member 4 is a member of the GIMAP (GTPase of the immunity-associated protein) family, which is enriched in hematopoietic cells. Research using GIMAP4 antibody has shown that it localizes to the cytoplasm and regulates T cell apoptosis by influencing mitochondrial membrane potential and caspase activation. These findings highlight its role in immune cell turnover and tolerance.

Studies with GIMAP4 antibody have demonstrated that loss of GIMAP4 function alters T cell lifespan, disrupting normal immune balance. In model organisms, deficiency of GIMAP4 results in prolonged T cell survival and immune dysregulation. Conversely, overexpression enhances apoptosis, suggesting that GIMAP4 fine-tunes immune cell homeostasis.

Dysregulation of GTPase IMAP family member 4 has been associated with autoimmune disease and cancer. Research using GIMAP4 antibody has shown that altered expression influences susceptibility to autoimmune conditions, where prolonged T cell survival contributes to autoreactivity. Reduced expression has been observed in certain leukemias, suggesting tumor suppressive functions.

GIMAP4 antibody is widely applied in immunohistochemistry, western blotting, and flow cytometry. Immunohistochemistry highlights expression in lymphoid tissues, western blotting quantifies levels in T cell lines, and flow cytometry identifies expression across immune cell subsets. These applications make GIMAP4 antibody indispensable in immunology research.

By providing validated GIMAP4 antibody reagents, NSJ Bioreagents supports studies into apoptosis, immune regulation, and disease. Detection of GTPase IMAP family member 4 provides researchers with insight into how GTPases regulate lymphocyte homeostasis and pathology.

UniProt: Q9NUV9