Glypican 3 Antikörper (AA 511-580) (CF®555)
Kurzübersicht für Glypican 3 Antikörper (AA 511-580) (CF®555) (ABIN7875532)
Target
Alle Glypican 3 (GPC3) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 511-580
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Verwendungszweck
- Glypican 3 Antibody
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Aufreinigung
- Protein G affinity chromatography
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Immunogen
- A recombinant fragment containing amino acids 511-580 from the human protein was used as the immunogen for the Glypican-3 antibody.
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Isotyp
- IgG1, kappa
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Applikationshinweise
- Optimal dilution of the Glypican 3 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Store the Glypican 3 antibody at 2-8oC, protected from light.
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- Glypican 3 (GPC3)
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Andere Bezeichnung
- Glypican 3
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Hintergrund
- Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100 % in follicular carcinoma and 70 % in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
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UniProt
- P51654
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Pathways
- Glycosaminoglycan Metabolic Process
Target
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