Glypican 3 Antikörper (GPC3)

Details for Product anti-GPC3 Antibody No. ABIN969523, Anbieter: Anmelden zum Anzeigen
Antigen
  • GPC3
  • sgb
  • dgsx
  • sdys
  • sgbs
  • oci-5
  • sgbs1
  • DGSX
  • GTR2-2
  • MXR7
  • OCI-5
  • SDYS
  • SGB
  • SGBS
  • SGBS1
  • Glypican-3
  • glypican 3
  • gpc3
  • GPC3
  • Gpc3
Reaktivität
Human, Maus
454
186
67
4
4
2
2
2
1
1
1
Wirt
Maus
257
202
4
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Glypican 3 Antikörper ist unkonjugiert
24
24
22
21
18
14
11
8
8
7
7
6
6
6
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
5
5
4
2
2
2
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
270
233
167
123
120
89
65
51
13
9
9
7
4
3
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Purified recombinant fragment of human GPC3 expressed in E. Coli.
Klon 9C2
Isotyp IgG1
Reinigung Purified
Plasmids, Primers & others Plasmide, Primers & weitere Glypican 3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung GPC3 (GPC3 Antibody Abstract)
Hintergrund Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Molekulargewicht 65.5 kDa
Gen-ID 2719
HGNC 2719
Pathways Glycosaminoglycan Metabolic Process
Applikations-hinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer PBS with 0.05 % sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
ELISA image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Flow Cytometry (FACS) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 2: Flow cytometric analysis of Jurkat cells using GPC3 mouse mAb (green) and n...
Immunocytochemistry (ICC) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 3: Immunofluorescence analysis of HeLa cells using GPC3 mouse mAb (green) . Bl...
Immunohistochemistry (IHC) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 4: Immunohistochemical analysis of paraffin-embedded liver cancer tissues usin...
Immunohistochemistry (IHC) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 5: Immunohistochemical analysis of paraffin-embedded breast cancer tissues usi...
Western Blotting (WB) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 6: Western blot analysis using GPC3 mouse mAb against HepG2 (1), HEK293 (2), J...
Western Blotting (WB) image for anti-Glypican 3 (GPC3) antibody (ABIN969523) Figure 7: Western blot analysis using GPC3 mAb against human GPC3 (AA: 55-200) recomb...
Produkt verwendet in: Zittermann, Capurro, Shi, Filmus: "Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 6, pp. 1291-301, 2010 (PubMed).

Takai, Ashihara, Ishiguro, Terashima, Watanabe, Kato, Suzuki: "Involvement of glypican-3 in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma." in: Cancer biology & therapy, Vol. 8, Issue 24, pp. 2329-38, 2010 (PubMed).

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