SIGLEC10 Antikörper (AA 500-697)

Produktnummer ABIN7875423

Der Maus Monoklonal anti-SIGLEC10 Antikörper wird verwendet zum Nachweis von SIGLEC10 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für SIGLEC10 Antikörper (AA 500-697) (ABIN7875423)

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIGLEC10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: SIGLEC10-7581

Produktdetails anti-SIGLEC10 Antikörper

Bindungsspezifität: AA 500-697

Verwendungszweck: SIGLEC10 Antibody

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 500-697) from the human protein was used as the immunogen for the SIGLEC10 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SIGLEC10 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SIGLEC10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Andere Bezeichnung: SIGLEC10

Hintergrund: Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.

UniProt: Q96LC7