SSH1 Antikörper (AA 489-921)

Produktnummer ABIN7875236

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SSH1 in WB, ELISA, IF, FACS und ICC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SSH1 Antikörper (AA 489-921) (ABIN7875236)

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-SSH1 Antikörper

Bindungsspezifität: AA 489-921

Verwendungszweck: SSH1 Antibody / Slingshot protein phosphatase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SSH1 recombinant protein (Position: E489-Y921) was used as the immunogen for the SSH1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SSH1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SSH1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SSH1

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Andere Bezeichnung: SSH1

Hintergrund: SSH1 antibody detects Slingshot protein phosphatase 1, a serine/threonine phosphatase that regulates actin filament dynamics by dephosphorylating cofilin. The UniProt recommended name is Slingshot protein phosphatase 1 (SSH1). This cytoplasmic enzyme is crucial for actin cytoskeleton remodeling during cell motility, adhesion, and morphogenesis.

Functionally, SSH1 antibody identifies a 1,047-amino-acid phosphatase that activates cofilin by removing inhibitory phosphate groups at serine 3. SSH1 operates downstream of Rho family GTPases and is controlled by 14-3-3 proteins, oxidative signals, and phosphorylation. It promotes lamellipodia formation and cytoskeletal reorganization during migration and neuronal outgrowth.

The SSH1 gene is located on chromosome 12q24.13 and is expressed in brain, muscle, and epithelial tissues. SSH1 integrates signals from LIM kinase and Rac/Cdc42 pathways to coordinate actin turnover and filament severing. Through cofilin activation, SSH1 drives rapid actin recycling necessary for directional movement and cell shape maintenance.

Pathologically, altered SSH1 activity contributes to cancer metastasis, neurological disorders, and cardiac hypertrophy. Dysregulated actin remodeling via SSH1-cofilin imbalance leads to defective migration and cytoskeletal instability. Research using SSH1 antibody supports studies in cytoskeletal dynamics, phosphatase signaling, and cell motility.

SSH1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect actin-regulating phosphatases. NSJ Bioreagents provides SSH1 antibody reagents optimized for studies in cell migration, cytoskeletal remodeling, and signal transduction.

Structurally, Slingshot protein phosphatase 1 contains an N-terminal cofilin-binding region and a catalytic domain related to the dual-specificity phosphatase family. This antibody aids in analyzing SSH1's control over actin filament turnover and cellular movement.

UniProt: Q8WYL5

Pathways: CXCR4-mediated Signaling Events