AMH Antikörper (C-Term)

Produktnummer ABIN7875132

Der Maus Monoklonal anti-AMH Antikörper wird verwendet zum Nachweis von AMH in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für AMH Antikörper (C-Term) (ABIN7875132)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AMH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: AMH-7354

Produktdetails anti-AMH Antikörper

Bindungsspezifität: AA 460-560, C-Term

Verwendungszweck: Anti Mullerian Hormone Antibody / AMH

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of the C-terminus of the human protein (within amino acids 460-560) was used as the immunogen for the Anti Mullerian Hormone antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Anti Mullerian Hormone antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Anti Mullerian Hormone antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Andere Bezeichnung: Anti Mullerian Hormone

Hintergrund: The transforming growth factor beta (TGF beta) superfamily is composed of numerous growth and differentiation factors, including TGF beta1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin Alpha, beta-A, beta-B and beta-C, Lefty and Nodal. Members of the TGF beta superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion