SOX4 Antikörper (AA 45-130)

Produktnummer ABIN7875054

Der Maus Monoklonal anti-SOX4 Antikörper wird verwendet zum Nachweis von SOX4 in Proben von Human. Er wurde validiert für WB, IHC (p), IF und FACS.

Kurzübersicht für SOX4 Antikörper (AA 45-130) (ABIN7875054)

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-SOX4-1D6

Produktdetails anti-SOX4 Antikörper

Bindungsspezifität: AA 45-130

Verwendungszweck: SOX4 Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 45-130 was used as the immunogen for the SOX4 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SOX4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot the SOX4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SOX4

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Andere Bezeichnung: SOX4

Hintergrund: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

UniProt: Q06945