Cathepsin B Antikörper (AA 42-339)

Produktnummer ABIN7874922

Der Kaninchen Polyklonal anti-Cathepsin B Antikörper wird verwendet zum Nachweis von Cathepsin B in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA, FACS und IHC (p).

Kurzübersicht für Cathepsin B Antikörper (AA 42-339) (ABIN7874922)

Target: Cathepsin B (CTSB)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Cathepsin B Antikörper

Bindungsspezifität: AA 42-339

Verwendungszweck: CTSB Antibody / Cathepsin B

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q42-K339) was used as the immunogen for the CTSB antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CTSB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CTSB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Cathepsin B

Target: Cathepsin B (CTSB)

Andere Bezeichnung: CTSB

Hintergrund: Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. And this gene is mapped to chromosome 8p22. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades