C9ORF72 Antikörper (AA 40-77)

Produktnummer ABIN7874711

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch C9ORF72 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für C9ORF72 Antikörper (AA 40-77) (ABIN7874711)

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C9ORF72 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-C9ORF72 Antikörper

Bindungsspezifität: AA 40-77

Verwendungszweck: Zebrafish C9orf72 Antibody

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish C9orf72 recombinant protein (amino acids R40-E77) was used as the immunogen for the Zebrafish C9orf72 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish C9orf72 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish C9orf72 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu C9ORF72

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Andere Bezeichnung: C9orf72

Hintergrund: C9orf72 (chromosome 9 open reading frame 72) is a protein which in humans is encoded by the gene C9orf72. It is mapped to 9p21.2. The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q6TLH8