Fascin Antikörper (AA 350-400)

Produktnummer ABIN7874186

Dieser Maus Monoklonal Antikörper detektiert spezifisch Fascin in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Fascin Antikörper (AA 350-400) (ABIN7874186)

Target: Fascin (FSCN1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fascin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: FSCN1-7209

Produktdetails anti-Fascin Antikörper

Bindungsspezifität: AA 350-400

Verwendungszweck: FSCN1 Antibody / Fascin 1

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 350-400 from the human FSCN1 protein was used as the immunogen for the FSCN1 antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FSCN1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the FSCN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Fascin

Target: Fascin (FSCN1)

Andere Bezeichnung: FSCN1

Hintergrund: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

UniProt: Q16658