Fascin Antikörper (AA 350-400)

Produktnummer ABIN7874184

Der Maus Monoklonal anti-Fascin Antikörper wird verwendet zum Nachweis von Fascin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Fascin Antikörper (AA 350-400) (ABIN7874184)

Target: Fascin (FSCN1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fascin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: FSCN1-7207

Produktdetails anti-Fascin Antikörper

Bindungsspezifität: AA 350-400

Verwendungszweck: Fascin 1 Antibody / FSCN1

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 350-400) from the human protein was used as the immunogen for the Fascin 1 antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Fascin 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Fascin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Fascin

Target: Fascin (FSCN1)

Andere Bezeichnung: Fascin 1

Hintergrund: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

UniProt: Q16658