STK39 Antikörper (AA 346-376)

Produktnummer ABIN7874119

Der Kaninchen Polyklonal anti-STK39 Antikörper (ABIN7874119) detektiert spezifisch STK39 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für STK39 Antikörper (AA 346-376) (ABIN7874119)

Target: STK39 (serine threonine Kinase 39 (STK39))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK39 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-STK39 Antikörper

Bindungsspezifität: AA 346-376

Verwendungszweck: SPAK Antibody / STK39

Aufreinigung: SAS precipitation

Immunogen: A portion of amino acids 346-376 from the human protein were used as the immunogen for the SPAK antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the SPAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SPAK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu STK39

Target: STK39 (serine threonine Kinase 39 (STK39))

Andere Bezeichnung: SPAK

Hintergrund: SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.

UniProt: Q9UEW8