ADRA2B Antikörper (AA 343-369)

Produktnummer ABIN7874107

Der Kaninchen Polyklonal anti-ADRA2B Antikörper (ABIN7874107) detektiert spezifisch ADRA2B in WB, IF, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ADRA2B Antikörper (AA 343-369) (ABIN7874107)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ADRA2B Antikörper

Bindungsspezifität: AA 343-369

Verwendungszweck: Alpha-2B Adrenergic Receptor Antibody / ADRA2B

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 343-369 from the human protein was used as the immunogen for the Alpha-2B Adrenergic Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Alpha-2B Adrenergic Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Alpha-2B Adrenergic Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Andere Bezeichnung: Alpha-2B Adrenergic Receptor

Hintergrund: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process