ADRA2B Antikörper

Produktnummer ABIN1944814

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ADRA2B in WB und IF. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für ADRA2B Antikörper (ABIN1944814)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-ADRA2B Antikörper

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IF: 1:100. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-ADRA2B Antikörper (ABIN1944814)

Cayla, Heinonen, Viikari, Schaak, Snapir, Bouloumié, Karvonen, Pesonen, Scheinin, Paris: "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene." in: Biochemical pharmacology, Vol. 67, Issue 3, pp. 469-78, (2004) (PubMed).

Small, Brown, Forbes, Liggett: "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4917-22, (2001) (PubMed).

Lomasney, Lorenz, Allen, King, Regan, Yang-Feng, Caron, Lefkowitz: "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 13, pp. 5094-8, (1990) (PubMed).

Weinshank, Zgombick, Macchi, Adham, Lichtblau, Branchek, Hartig: "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor." in: Molecular pharmacology, Vol. 38, Issue 5, pp. 681-8, (1990) (PubMed).

Details zu ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Andere Bezeichnung: Adrenergic Receptor alpha-2B

Hintergrund: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Molekulargewicht: 49954 Da

Gen-ID: 151

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process