Presenilin 1 Antikörper (AA 330-359)

Produktnummer ABIN7874018

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Presenilin 1 in WB, IF, FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Presenilin 1 Antikörper (AA 330-359) (ABIN7874018)

Target: Presenilin 1 (PSEN1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Presenilin 1 Antikörper

Bindungsspezifität: AA 330-359

Verwendungszweck: Presenilin 1 Antibody / PSEN1

Aufreinigung: Purified

Immunogen: A portion of amino acids 330-359 from the human protein was used as the immunogen for the Presenilin 1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Presenilin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Presenilin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Presenilin 1

Target: Presenilin 1 (PSEN1)

Andere Bezeichnung: Presenilin 1

Hintergrund: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

UniProt: P49768

Pathways: Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport