ITM2C Antikörper (AA 33-226)

Produktnummer ABIN7873992

Der Kaninchen Polyklonal anti-ITM2C Antikörper wird verwendet zum Nachweis von ITM2C in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für ITM2C Antikörper (AA 33-226) (ABIN7873992)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITM2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-ITM2C Antikörper

Bindungsspezifität: AA 33-226

Verwendungszweck: ITM2C Antibody / Integral membrane protein 2C

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human ITM2C recombinant protein (Position: E33-D226) was used as the immunogen for the ITM2C antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ITM2C antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ITM2C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Andere Bezeichnung: ITM2C

Hintergrund: ITM2C antibody detects Integral membrane protein 2C, a type II transmembrane protein implicated in neuronal differentiation, amyloid precursor protein (APP) metabolism, and synaptic maintenance. Encoded by the ITM2C gene on chromosome 11q25, this protein belongs to the BRICHOS superfamily, whose members are involved in protein folding, trafficking, and neuroprotection. ITM2C is highly expressed in the central nervous system, particularly in the hippocampus and cerebral cortex, where it contributes to synaptic function and neuroplasticity.

Structurally, ITM2C contains a short cytoplasmic N-terminal tail, a single transmembrane domain, and a large luminal BRICHOS domain that assists in proper folding of amyloidogenic proteins. ITM2C interacts with APP and modulates its processing by influencing the activity of secretases, thereby reducing amyloid beta peptide production. This regulatory function positions ITM2C as a potential protective factor against neurodegenerative diseases such as Alzheimer's disease.

The ITM2C antibody is widely used in neuroscience and neurodegeneration research to study synaptic organization, APP metabolism, and BRICHOS domain biology. Western blot analysis detects a 30 kilodalton band corresponding to ITM2C, while immunofluorescence reveals Golgi and vesicular localization within neurons and glial cells. This antibody supports investigations into the cellular pathways controlling amyloid processing and synaptic stability.

Loss or dysregulation of ITM2C has been associated with cognitive decline and neuroinflammation. Reduced expression leads to impaired APP trafficking and enhanced amyloid accumulation, while overexpression protects against oxidative and excitotoxic stress. Beyond the brain, ITM2C is expressed in pancreatic islets, suggesting additional roles in endocrine regulation. The ITM2C antibody provides a powerful tool for elucidating mechanisms of protein homeostasis and synaptic maintenance in health and disease. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and consistent performance in neurobiology research.

UniProt: Q9NQX7