SUN1 Antikörper (AA 32-619)

Produktnummer ABIN7873935

Der Kaninchen Polyklonal anti-SUN1 Antikörper wird verwendet zum Nachweis von SUN1 in Proben von Human. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für SUN1 Antikörper (AA 32-619) (ABIN7873935)

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SUN1 Antikörper

Bindungsspezifität: AA 32-619

Verwendungszweck: SUN1 Antibody / Sad1/UNC-84 domain-containing protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SUN1 recombinant protein (Position: D32-E619) was used as the immunogen for the SUN1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SUN1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SUN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SUN1

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Andere Bezeichnung: SUN1

Hintergrund: SUN1 antibody detects Sad1/UNC-84 domain-containing protein 1, encoded by the SUN1 gene on chromosome 7p22.3. SUN1 antibody is widely used in nuclear envelope, cytoskeletal, and cell structure research. SUN1 is an inner nuclear membrane protein that interacts with KASH domain proteins at the outer nuclear membrane to form the LINC (linker of nucleoskeleton and cytoskeleton) complex. This complex physically connects the nuclear interior with the cytoskeleton, enabling nuclear positioning, mechanotransduction, and chromosome dynamics.

Structurally, SUN1 is a ~90 kDa type II transmembrane protein with a conserved SUN domain that extends into the perinuclear space. It anchors to the nuclear lamina and interacts with chromatin-associated proteins inside the nucleus. SUN1 can heterodimerize with SUN2 to form diverse LINC complexes. Expression is ubiquitous, with enrichment in proliferating and differentiating cells.

Functionally, SUN1 regulates nuclear migration, anchorage, and mechanotransduction. It is essential for meiotic chromosome pairing, telomere tethering, and centrosome-nucleus coupling. SUN1 also contributes to DNA repair and genomic stability. Researchers use SUN1 antibody to study nuclear organization, mechanobiology, and chromosome dynamics.

Clinically, SUN1 mutations and dysregulation are associated with laminopathies, muscular dystrophies, and neurodevelopmental disorders. Disruption of the LINC complex impairs nuclear positioning and mechanosignaling, leading to disease. SUN1 also contributes to cancer progression by altering nuclear morphology and chromatin organization. NSJ Bioreagents provides SUN1 antibody for research in nuclear architecture, mechanobiology, and disease mechanisms.

Experimentally, SUN1 antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to visualize nuclear envelope localization, and in immunohistochemistry to study tissue-specific expression. Co-immunoprecipitation with SUN1 antibody identifies binding partners within the LINC complex.

UniProt: O94901

Pathways: Maintenance of Protein Location