CD276 Antikörper (AA 7-3, AA 29-458)

Produktnummer ABIN7873425

Der Kaninchen Polyklonal anti-CD276 Antikörper wird verwendet zum Nachweis von CD276 in Proben von Human. Er wurde validiert für WB, ELISA, FACS und IHC (p).

Kurzübersicht für CD276 Antikörper (AA 7-3, AA 29-458) (ABIN7873425)

Target: CD276

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD276 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CD276 Antikörper

Bindungsspezifität: AA 7-3, AA 29-458

Verwendungszweck: B7-H3 Antibody / CD276

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids L29-Q458) was used as the immunogen for the B7-H3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the B7-H3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the B7-H3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CD276

Target: CD276

Andere Bezeichnung: B7-H3

Hintergrund: Cluster of Differentiation 276 (CD276) or B7 Homolog 3 (B7-H3) is a human protein encoded by the CD276 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints