GSTA4 Antikörper (AA 29-222)

Produktnummer ABIN7873400

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GSTA4 in WB, ELISA, FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Affe.

Kurzübersicht für GSTA4 Antikörper (AA 29-222) (ABIN7873400)

Target: GSTA4 (Glutathione S-Transferase alpha 4 (GSTA4))

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSTA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GSTA4 Antikörper

Bindungsspezifität: AA 29-222

Verwendungszweck: GSTA4 Antibody

Aufreinigung: Affinity purified

Immunogen: A human recombinant partial protein (amino acids E29-P222) was used as the immunogen for the GSTA4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GSTA4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GSTA4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GSTA4

Target: GSTA4 (Glutathione S-Transferase alpha 4 (GSTA4))

Andere Bezeichnung: GSTA4

Hintergrund: Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules). In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.

UniProt: O15217